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Comparing Pain Relief Medications for Total Knee Replacement Surgery

This study is comparing two different medication combinations to see which provides the best and longest-lasting pain relief after total knee replacement surgery. You might be eligible if you are between 18 and 80 years old, having your first total knee replacement, and meet certain health criteria (ASA category 1 to 3). The study is testing Liposomal Bupivacaine against a combination of Bupivacaine, Clonidine, Epinephrine, Buprenorphine, and Dexamethasone. Researchers will measure your pain scores at different times after your surgery to determine which treatment is more effective. The study aims to enroll 90 participants, but its current status is unclear.

Study design
This is a double-blinded (meaning neither you nor your doctors will know which treatment you receive) randomized control trial involving approximately 90 participants.
What's involved
You would receive a spinal anesthetic and two types of nerve blocks. Your pain scores will be collected at 4 and 8 hours after your block, and then on post-operative days 1 and 2 at 7 AM, 12 PM, and 5 PM.
Compensation
Not stated in the trial record.
Follow-up
Pain scores will be collected up to post-operative day 2.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07097493

Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty

Not Yet Recruiting
PHASE4Ages 18+InterventionalTreatment
Wake Forest University Health Sciences
~90 participants
Updated 2026-08-25 on ClinicalTrials.gov
What's tested:Liposomal BupivacaineBupivacaine, Clonidine, Epinephrine, Buprenorphine and Dexamethasone (BPV-CEBD) Combination

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Pain Score with Movement
Measured over Baseline
+2 more outcomes measured

Conditions

Knee Arthroplasty, Total

Explore related trials

Total Knee Replacement

Where it's being run

1 sites across 1 states
North Carolina1

Study leadership

  • Afua Gyamfi, MD · PRINCIPAL_INVESTIGATOR · Atrium Health Wake Forest Baptist

Who to contact

Afua Gyamfi, MD
[email protected]
336-716-4498
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

18-80 years of age
Receiving primary total knee arthroplasty
Patients receiving a spinal anesthetic with ropivacaine and fentanyl
American Society of Anesthesiology (ASA) category 1 to 3

Exclusion

Revision of Total Knee Arthroplasty
Opioid use in the prior 6 months \> 40 mg oxycodone equivalents per day or long-acting opioids as determined by the Prescription Drug Monitoring Program (PDMP)
Patients planned to receive general anesthesia
Patients planned to receive a spinal other than ropivacaine
History of peripheral neuropathy
Poorly controlled diabetes (Hgb A1C \>8)
Allergies or contraindications to study medications: acetaminophen, celecoxib (including sulfa), methocarbamol, midazolam, fentanyl, bupivacaine, dexamethasone, acetaminophen, buprenorphine, NSAIDs, clonidine, epinephrine, and liposomal bupivacaine.
Unable to provide informed consent

What this trial measures

  • Pain Score with MovementBaseline

    numerical rating scale pain score with movement utilizing the numerical rating pain score scale of 0 to 10, where 0 is no pain and 10 is the worst imaginable pain

  • Pain Score with MovementHour 4 post final block placement

    numerical rating scale pain score with movement utilizing the numerical rating pain score scale of 0 to 10, where 0 is no pain and 10 is the worst imaginable pain

  • Pain Score with MovementHour 8 post final block placement

    numerical rating scale pain score with movement utilizing the numerical rating pain score scale of 0 to 10, where 0 is no pain and 10 is the worst imaginable pain