This study is looking at different ways to give vancomycin, an antibiotic, to prevent infections after total knee replacement surgery (TKA). Researchers want to see if injecting vancomycin directly into the joint (intraarticular) works as well as injecting it into the bone (intraosseous). The goal is to find a method that is just as effective but might involve fewer wounds, less time, and lower costs. You might be able to join if you are over 18, having your first knee replacement at UC San Diego Health, and don't have certain health conditions like a high BMI, uncontrolled diabetes, or allergies to the study medications. The main thing they will measure is how much vancomycin is found in your bone, joint tissue, fat, and blood during surgery. The study plans to enroll 30 participants, and its current status is unclear.

Study design

This interventional study plans to enroll 30 participants. It is comparing two ways of giving vancomycin.

What's involved

Not specified in the trial record.

Compensation

Not stated in the trial record.

Follow-up

The primary measurements are taken during surgery (intraoperative).

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.