Aprepitant to Improve Same Day Discharge for TKA
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Steven Greenberg, MD · PRINCIPAL_INVESTIGATOR · Endeavor Health
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Inclusion
Exclusion
What this trial measures
- difference in the incidence of same-day discharges between two randomized groups of anti-emetic regimens for anesthesia carepatients will be followed from arrival for surgery to 7 days post operatively
difference in the incidence of same-day discharges between two randomized groups of anti-emetic regimens for anesthesia care. Subjects will be randomized to either the aprepitant group (administration of aprepitant, ondansetron, and dexamethasone) or control (ondansetron, dexamethasone, and placebo). PACU and ASU staff will collect real time data with regard to the primary and secondary reason for any hospital admission (PONV, Pain control, Rapid response team called, Vital sign abnormalities, Change in mental status, Other). Same day discharge will be defined by patients who are discharged from the hospital before 12 A.M day of surgery. We will use the validated simplified PONV Impact Scale that uses patient assessment of nausea and vomiting to identify clinically important PONV upon PACU and ASU discharge (a PONV impact scale score of greater than or equal to 5 defines clinically important PONV).