This study is testing if a combination of Personalized, Augmented Cognitive Training (PACT) and intermittent theta burst stimulation (iTBS) can help treat depression in people who have had a mild traumatic brain injury (mTBI), also known as a concussion. You could be eligible if you are 18 to 65 years old, have a history of mTBI, and are a military service member or civilian receiving treatment at NMCSD or UCSD Health. Participants will receive PACT along with either iTBS or a sham (inactive) iTBS over four weeks. Researchers will measure changes in depression using the Hamilton Rating Scale for Depression over eight weeks to see if the PACT+iTBS combination is more effective. The study is currently recruiting 72 participants.

Study design

This interventional study plans to enroll 72 participants. It compares two groups: one receiving PACT plus iTBS, and another receiving PACT plus sham iTBS.

What's involved

You would receive 6 sessions of PACT and 20 sessions of iTBS or sham iTBS over 4 weeks. Assessments will take place at baseline, 2 weeks, 4 weeks, and 8 weeks.

Compensation

Not stated in the trial record.

Follow-up

Your depression levels will be assessed for 8 weeks after the start of the study.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.