Adolescent Depression and Sleep Study
This study is looking at how sleep affects depression and anhedonia (a reduced ability to feel pleasure) in teenagers. It's an interventional study, meaning participants will receive a specific intervention. Researchers want to understand the link between sleep, stress, and brain function. You could be eligible if you are 14-18 years old, in high school, and have either short and late sleep (sleeping 7 hours or less and going to bed at 10:30 pm or later) or long and early sleep (sleeping more than 7 hours and going to bed at 10:30 pm or earlier). The study will compare two groups: one that extends and advances their sleep schedule, and another that maintains their regular sleep schedule. Success will be measured by changes in depression and positive mood, as well as anhedonia, after two months. The current recruitment status is unclear, and the study aims to enroll 150 participants.
- Study design
- This is an interventional study with an unspecified phase, involving approximately 150 participants. It compares two behavioral interventions related to sleep.
- What's involved
- Participants will either follow a sleep schedule that extends their sleep duration and advances their bedtime, or maintain their regular sleep schedule. Schedule adherence will be reinforced.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants' outcomes will be measured at 2 months after the intervention begins.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Mechanisms of Depression and Anhedonia in Adolescents: Linking Sleep to Reward- and Stress-Related Brain Function
At a glance
Conditions
NCT05691439
Where you'd take part
This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.
University of Oregon
Eugene, Oregonstudy coordinator listed
Recruiting
Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.
Study leadership
- Melynda D Casement, PhD · PRINCIPAL_INVESTIGATOR · University of Oregon
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Depression Scale - Short Form (8-item)2 months
The Patient-Reported Outcomes Measurement Information System (PROMIS) scale for Depression (8-item short form) will be administered at baseline, after each 2-week interval of intensive monitoring, and at follow-up, in reference to the past 7 days. The measure uses 5-point Likert scales, with scores ranging from 8 to 40 and higher scores indicating higher depression and lower scores indicating better outcome. Raw scores are converted to standardized T-scores using conversion tables published on the PROMIS website (nihpromis.org). T-scores of 50 represent the mean of the standardized sample.
- Patient-Reported Outcomes Measurement Information System (PROMIS) Pediatric Positive Affect Scale - Short Form (8-item)2 months
The Patient-Reported Outcomes Measurement Information System (PROMIS)scale for Positive Affect (8-item short form) will be administered at baseline, after each 2-week interval of intensive monitoring, and at follow-up, in reference to the past 7 days. The measure uses 5-point Likert scales, with scores ranging from 8 to 40 and higher scores indicating higher positive affect and better outcome. Raw scores are converted to standardized T-scores using conversion tables published on the PROMIS website (nihpromis.org). T-scores of 50 represent the mean of the standardized sample.
- Dimensional Anhedonia Rating Scale (DARS)2 months
The Dimensional Anhedonia Rating Scale (DARS) will be used to assess state anhedonia related to 4 domains: hobbies, food/drink, social activities, and sensory experience. The 17-item measure assesses hedonic experiences "right now" using 4-point Likert scales. The DARS has high reliability and good convergent and divergent validity. The DARS scores range from 0 to 68, with higher scores indicating lower anhedonia and better outcome.
- Reward-related brain function2 weeks
Functional magnetic resonance imaging (fMRI) during the Monetary Incentive Delay (MID) task will be used to measure blood oxygen level dependent (BOLD) regional response and functional connectivity related to anticipation and receipt of monetary rewards. This task reliably elicits activation in neural reward circuitry and is sensitive to depression and sleep/circadian factors.
- Stress-related brain function2 weeks
Stress-related brain function will be indexed using autonomic and neuroendocrine measures taken before and during the Trier Social Stress Task (TSST). The TSST is a lab-based social-evaluative threat task that reliably elicits subjective stress and increases in the stress-hormone cortisol.