Mobile App Therapy for Anxiety, Depression, and Bipolar Disorder

This study is testing two versions of a mobile app called MAYA to help young adults (ages 18-25) with anxiety, depression, or bipolar disorder. One version, the Personalized MAYA Mobile App, focuses on skills tailored to your specific symptoms and introduces new material over the first four weeks. The other, the General MAYA Mobile App, introduces new skills over the full six weeks. Researchers want to see if the personalized app is just as good at reducing anxiety and depression symptoms. Success will be measured by changes in your anxiety and depression scores. The study plans to enroll 100 participants, but its current recruitment status is unclear.

Study design
This interventional study will randomly assign participants to one of two versions of the MAYA app. It aims to enroll 100 participants.
What's involved
You would use the Maya app for two days per week, at least 20 minutes per day, for six weeks. You will also have weekly check-ins, complete questionnaires, and may have optional EEG recordings at the beginning and end of the intervention.
Compensation
Not stated in the trial record.
Follow-up
You will have a follow-up assessment at week 12, after the 6-week intervention.

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NCT05699525

Personalized Mobile Cognitive Behavioral Therapy Application

Recruiting
NAAges 18–25InterventionalTreatment
Weill Medical College of Cornell University
~100 participants
Updated 2026-05-22 on ClinicalTrials.gov
What's tested:Personalized MAYA Mobile AppGeneral MAYA Mobile App

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in anxiety symptoms from pre-intervention to post-intervention as measured by the HAM-A.
Measured over Baseline to endpoint [Week 6]
+3 more outcomes measured
Anxiety Disorders and Symptoms
Depression
Bipolar Disorder
Symptoms
1 sites across 1 states
New York1
  • Jennifer Bress, Ph.D. · PRINCIPAL_INVESTIGATOR · Weill Medical College of Cornell University

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Eligibility criteria

Inclusion

Age between 18 and 25 years.
Primary diagnosis of an anxiety, depressive, or bipolar disorder as determined by a score of 4 or greater on the Clinical Severity Rating of the Anxiety Disorders Interview Schedule (ADIS).
If an individual is diagnosed with bipolar disorder, they must be currently euthymic or experiencing a depressive episode.
Access to an Apple iPhone, iPad, or Android device.

Exclusion

History of neurologic disorder that may affect the neural systems of interest or participant's ability to participate
Lifetime diagnosis of a psychotic disorder.
Current hypomanic or manic episode.
Currently in cognitive behavior therapy.
Change in dose of a psychiatric medication in the past 12 weeks.
Initiation of psychotherapy in the past 12 weeks.
Intent or plan to attempt suicide.
  • Change in anxiety symptoms from pre-intervention to post-intervention as measured by the HAM-A.Baseline to endpoint [Week 6]

    The primary symptom measure for anxiety will be the Hamilton Rating Scale for Anxiety (HAM-A). The HAM-A is a 14-item questionnaire measure of the severity of anxiety symptoms. The items measure both psychic anxiety and somatic anxiety. The scores range from 0 to 56, where higher scores indicate a greater severity of symptoms and lower scores indicate mild to no anxiety symptoms.

  • Change in depressive symptoms from pre-intervention to post-intervention as measured by HAM-D.Baseline to endpoint [Week 6]

    The primary symptom measure for depression will be the Hamilton Rating Scale for Depression (HAM-D). The HAM-D is a 24-item questionnaire measuring the severity of depression symptoms. The scale ranges from 0 to 76, where higher scores indicate higher severity of depressive symptoms.

  • Change in anxiety symptoms from pre-intervention to post-intervention as measured by the anxiety subscale of the DASS.Baseline to endpoint [Week 6]

    Anxiety will be measured by the anxiety subscale of the Depression Anxiety Stress Scale (DASS). The anxiety subscale measures of the severity of anxiety symptoms. The scores range from 0 to 42, where higher scores indicate a greater severity of symptoms and lower scores indicate mild to no anxiety symptoms.

  • Change in depressive symptoms from pre-intervention to post-intervention as measured by the depression subscale of the DASS.Baseline to endpoint [Week 6]

    Depression will be measured by the depression subscale of the Depression Anxiety Stress Scale (DASS). The subscale measures of the severity of depressive symptoms. The scores range from 0 to 42, where higher scores indicate a greater severity of symptoms and lower scores indicate mild to no symptoms.