Intracranial Investigation of Neural Circuitry Underlying Human Mood
This study is investigating how brain activity relates to mood in people with depression or epilepsy. Researchers are using brain stimulation (a device that sends electrical signals to the brain) and sEEG stimulation (stimulation delivered through electrodes placed inside the brain) to understand the brain's role in mood. You could be eligible if you are between 21 and 70 years old. If you have epilepsy, you must be scheduled for intracranial seizure monitoring. If you have depression, you must already be enrolled in a deep brain stimulation (DBS) trial for depression. The study will measure daily mood using a specific assessment (CAT-DI) over 10 days for epilepsy patients and 2 weeks for depression patients to see how the interventions affect mood. The current recruitment status is unclear.
- Study design
- This is an interventional study with a planned enrollment of 58 participants. It includes two groups: people with epilepsy and people with depression.
- What's involved
- Participants will have electrodes implanted inside their brain (sEEG). Those with depression will also have deep brain stimulation (DBS) leads implanted. Daily mood assessments will be taken for 10 days (epilepsy) or 2 weeks (depression).
- Compensation
- Not stated in the trial record.
- Follow-up
- Mood will be assessed for 10 days in epilepsy patients and 2 weeks in depression patients.
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Intracranial Investigation of Neural Circuity Underlying Human Mood
At a glance
Conditions
Where it's being run
1 sites across 1 statesWho to contact
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Do you actually qualify for this trial?
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Inclusion
What this trial measures
- Daily Mood Assessment - CAT-DIEpilepsy patients: 10 days; Depression: 2 weeks
Across both Depression and Eplipsy Cohorts, we will measure naturally occurring mood variations by periodically administering the Computerized Adaptive Test Depression Inventory (CAT-DI) mood assessment tool. Its adaptive nature makes CAT-DI fast to administer (1 minute) while maintaining precision and correlation with conventional depression scales such as the Hamilton Depression Inventory. We will administer CAT-DI 7-10 times per day to capture natural variations in mood over hours to days. We will also induce mood variation by allowing subjects to watch a series of short (45-60 sec) videos with emotionally valenced content spanning negative to positive (72 total videos).