This study is looking at whether changes in diet and lifestyle can help prevent or delay Alzheimer's disease in adults with Down syndrome. You could be eligible if you are an adult with Down syndrome, aged 18-64, have a BMI (Body Mass Index) between 25 and 50, can speak, and live with a caregiver who helps with meals. Participants will either follow a reduced-calorie diet with frozen meals and increased fruits/vegetables, or receive general health education. Researchers will measure blood markers like Amyloid beta 42:40 ratio and Neurofilament light, as well as weight, to see if these lifestyle changes are helpful. The study aims to enroll 81 participants.

Study design

This is an interventional study where participants will be randomly assigned to either a weight loss group or a general health education group. The study plans to enroll 81 participants.

What's involved

You would need to come to the University of Kansas Medical Center 3 times over one year for testing. The weight loss group will follow a reduced energy diet, attend monthly remote education sessions, and self-monitor diet and weight. The control group will attend monthly remote general health education sessions.

Compensation

Not stated in the trial record.

Follow-up

Measurements will be taken at the beginning of the study, and again at 6 and 12 months.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.