Amplification of Positivity for Alcohol Use Study
This study is testing a new behavioral therapy called Amplification of Positivity Therapy (AMP) for people with alcohol use disorder, especially those who also experience depression or anxiety. It compares AMP with Cognitive Behavioral Therapy. Researchers want to see if AMP helps improve your mood and reduce drinking days. They will also ask about your satisfaction with the treatment. You may be able to join if you are between 18 and 65 years old, have alcohol use disorder, and want to seek treatment for it. The study is currently unclear about its recruitment status, but plans to enroll 100 participants.
- Study design
- This interventional study plans to enroll 100 participants. It will compare Amplification of Positivity Therapy with Cognitive Behavioral Therapy.
- What's involved
- Participants will answer questions about their mental and physical health and substance use through computer surveys and interviews. Treatment will last for about 16 weeks.
- Compensation
- Not stated in the trial record.
- Follow-up
- Participants will be followed for about 16 weeks after starting treatment.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Amplification of Positivity for Alcohol Use
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Robin L Aupperle, PhD · PRINCIPAL_INVESTIGATOR · Laureate Institute for Brain Research
Who to contact
Opens a ready-to-send draft in your own email app — review before sending.
What this trial measures
- Perceived acceptability and satisfaction of the intervention as measured with the Adherence and Acceptability Scale (AAS)Average of total scores from the following time points: pre-treatment, 2 weeks after starting treatment, 6 weeks after starting treatment, and at post-treatment (average of 16 weeks after baseline assessment)
This measure assesses the acceptability and tolerability of the intervention and is the primary outcome for Phase 1. Scores may range from 10 to 70, with higher scores indicating greater acceptability of treatment and greater anticipated ability to adhere to it.
- Change in positive affect self-report measured with National Institute of Health (NIH) Patient Reported Outcome Measurement and Information System (PROMIS) Positive Affect scoreTrajectory of change from pre-treatment to post-treatment (last time point assessed on average 16 weeks after baseline assessment)
National Institute of Health (NIH) Patient Reported Outcome Measurement and Information System (PROMIS) Positive Affect Scale, which is reported as a T score. The score is presented as a T score with a mean of 50 and a standard deviation of 10, with a range of 0-100. Higher scores indicate greater positive affect or better outcome. This is a primary outcome for Phase 2.
- Change in number of drinking days in the past monthTrajectory of change from pre-treatment to post-treatment (last time point assessed on average 16 weeks after baseline assessment)
As measured through self-reported drinking days using Timeline Followback. This is a primary outcome for Phase 2.