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Study on Motivational Interviewing and Mindfulness for Polysubstance Use

This study is testing different approaches to help people reduce their use of opioids, tobacco, and other drugs. It combines Mindfulness-Oriented Recovery Enhancement (MORE) sessions, motivational interviewing (a type of counseling), and nicotine replacement therapy (NRT). Researchers want to see how well these combinations work to decrease drug and tobacco use. You might be able to join if you are at least 18 years old, speak English, are currently on methadone, and smoke cigarettes. The study is looking for 420 participants. The current status of the study is unclear, so it's not known if they are actively recruiting.

Study design
This interventional study plans to enroll 420 participants. It compares four different combinations of support groups, motivational interviewing, and Mindfulness-Oriented Recovery Enhancement (MORE) sessions, all with nicotine replacement therapy.
What's involved
You would attend eight group sessions and potentially one motivational interviewing session. The study will track your drug and tobacco use for up to 52 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your drug and tobacco use will be measured from the start of the study through 52 weeks.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06033599

Motivational Interviewing and Mindfulness-Oriented Recovery Enhancement

Recruiting
PHASE3Ages 18+InterventionalTreatment
Rutgers, The State University of New Jersey
~420 participants
Updated 2026-07-17 on ClinicalTrials.gov
What's tested:MORE and MI and NRTMORE and No MI and NRTSupport Group and MI and NRTSupport Group and No MI and NRT

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Days of Drug Use
Measured over Baseline through 52 weeks.
+1 more outcome measured

Conditions

Polysubstance Abuse
Opioid Use
Tobacco Use

Explore related trials

Opioid Use DisorderSubstance use disorderTobacco Use Disorder

Where it's being run

2 sites across 2 states
New Jersey1
Utah1

Study leadership

  • Nina Cooperman, PsyD · PRINCIPAL_INVESTIGATOR · Rutgers Robert Wood Johnson Medical School

Who to contact

Nina Cooperman, PsyD
[email protected]
732-235-8569
Email the study team

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Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Inclusion

English-speaking
Age ≥18
Currently on methadone; and 4) currently smoke cigarettes.

Exclusion

Severe cognitive impairment (score \>23 on Mini Mental Status Exam) or psychosis (positive SCID Psychotic Screen)
Suicidal risk (score ≥7 on Suicidal Behaviors Questionnaire)
Inability to attend or fully participate in intervention sessions or assessments
Previous formal mindfulness training (e.g., MBSR, MBRP) or MORE (from the R21 or R33
Currently taking smoking cessation pharmacotherapy or participating in smoking cessation counseling
Any contraindications for NRT
Currently or soon planning to be pregnant or breastfeeding.

What this trial measures

  • Days of Drug UseBaseline through 52 weeks.

    Number of days of drug use as measured by self-reported days of use and biochemically verified use via drug screen.

  • Days of Tobacco UseBaseline through 52 weeks.

    Number of days of tobacco use as measured by self-reported days of use and biochemically verified use via expired carbon monoxide.