Vagal Nerve Stimulation and Gastric Function Study

This study is looking at how vagal nerve stimulation (VNS) affects stomach functions like how quickly food leaves the stomach (gastric emptying) and how much the stomach can stretch to hold food (gastric accommodation). VNS involves a device that sends electrical impulses to the vagus nerve, which can help with conditions like epilepsy and depression, and also sends impulses to the stomach. Researchers want to see if VNS increases the stomach's ability to stretch and speeds up how fast food empties from it. They will compare results from 12 participants who already have a VNS device implanted for drug-resistant depression with information from healthy individuals. The study is currently unclear on its recruitment status and aims to enroll 16 participants.

Study design
This is a single-cohort study involving 12 participants who already have a Vagus Nerve Stimulant device implanted. Researchers will compare their results to data from healthy individuals.
What's involved
You would need to attend one visit, which is expected to take about 4.5 hours. During this visit, you would undergo a combined gastric emptying and accommodation test.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06038929

Effect of Vagal Nerve Stimulation on Gastric Motor Functions

Recruiting
NAAges 18+Interventional
Mayo Clinic
~16 participants
Updated 2025-10-14 on ClinicalTrials.gov
What's tested:Vagal nerve stimulant

At a glance

Recruiting sites
2 of 2 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Gastric emptying T1/2
Measured over during 4 hour gastric emptying test
+1 more outcome measured
Depression
Epilepsy
2 sites across 1 states
Minnesota2
  • Michael Camilleri · PRINCIPAL_INVESTIGATOR · Mayo Clinic

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  • Gastric emptying T1/2during 4 hour gastric emptying test

    time to empty 50% of the whole stomach contents

  • Gastric accommodationduring first 1 hour of gastric emptying test

    gastric delta volume (postprandial minus fasting) for the whole stomach