Study for Anxiety, Depression, and PTSD Symptoms

This study is testing a computer-based program called COGENT to see if it can improve thinking skills in people with anxiety, depression, or post-traumatic stress disorder (PTSD). You would be randomly assigned to either receive COGENT or a similar program called Sham Program, which researchers believe will be less effective. The study aims to see if COGENT can help reduce repetitive negative thoughts by improving cognitive performance (how well your brain processes information). To join, you need to be between 21 and 55 years old, speak English, have a diagnosis of a mood, anxiety, or traumatic stress disorder, and experience clinically elevated repetitive negative thinking. The study is currently unclear on its recruitment status.

Study design
This is an interventional study where 128 participants will be randomly assigned to one of two groups. One group will receive the COGENT program, and the other will receive a Sham Program.
What's involved
Your cognitive performance will be measured at the start of the study (Baseline), and again at Week 4, Week 8, and Week 16.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for cognitive performance up to Week 16 after starting the study.

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NCT06273527

Enhancing Transdiagnostic Mechanisms of Cognitive Dyscontrol (R33)

Recruiting
PHASE2Ages 21–55InterventionalTreatment
University of California, San Diego
~128 participants
Updated 2025-10-24 on ClinicalTrials.gov
What's tested:COGENTSham Program

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Change in cognitive performance
Measured over Baseline, Week 4, Week 8, Week 16
Anxiety Disorders
Depression
Post Traumatic Stress Disorder
1 sites across 1 states
California1

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Eligibility criteria

Inclusion

age 21-55
fluent in English
diagnosis of mood, anxiety, or traumatic stress disorder
clinically elevated repetitive negative thinking
outpatient status
6-week stability if taking selective serotonin reuptake inhibitor (SSRI) medications

Exclusion

past year diagnosis of severe alcohol or moderate or greater substance use disorder
lifetime history of psychotic or bipolar I disorder
acute suicidality necessitating immediate clinical intervention
neurodegenerative or neurodevelopmental disorders
history of moderate or severe traumatic brain injury or other known neurological condition
sensory deficits that would preclude completing tasks
conditions unsafe for completing MRI scanning (e.g., metal in body)
current pregnancy
currently receiving psychosocial treatment
currently receiving psychiatric pharmacotherapy, except SSRIs
  • Change in cognitive performanceBaseline, Week 4, Week 8, Week 16

    Span Working Memory Score. Scores are calculated based on memory accuracy total points across all trials, with higher scores indicating better performance. This change is expected to be significantly higher for the COGENT group than the Sham group.