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Attention Bias Modification for Depression

This study is testing different ways to help adults with depression by training their attention. It compares two types of "Attention Bias Modification" (ABM) – Traditional ABM and Gamified ABM – against a Sham ABM. ABM is a behavioral intervention that aims to shift attention away from negative things. The study wants to see if the gamified version is as good as or better than traditional ABM, and if both are more effective than the sham treatment. To join, you need to be between 18 and 70 years old, fluent in English, and have a certain score on a depression questionnaire (QIDS-SR of 13 or higher). You also can't have changed your antidepressant medication in the last 12 weeks. The study will measure success by looking at changes in your depression symptoms using the QIDS-SR questionnaire. The study plans to enroll 600 people, but its current recruitment status is unclear.

Study design
This is an interventional study comparing three different behavioral treatments for depression. It plans to enroll 600 participants.
What's involved
You will complete self-report questionnaires, do eye-tracking tasks, and have clinical interviews with researchers. The study will measure your depression symptoms at screening, baseline, weekly for the first four weeks, and then at weeks 12-28.
Compensation
Not stated in the trial record.
Follow-up
Your depression symptoms will be followed for up to 28 weeks after the initial treatment period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06361095

Confirmatory Efficacy Trial of Attention Bias Modification for Depression

Recruiting
EARLY_PHASE1Ages 18–70InterventionalTreatment
University of Texas at Austin
~600 participants
Updated 2025-09-15 on ClinicalTrials.gov
What's tested:Traditional Attention Bias ModificationGamified Attention Bias ModificationSham Attention Bias Modification

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
QIDS (Quick Inventory of Depression Symptoms) SR-16
Measured over Screening, Baseline, Weeks 1-4 (Acute Period), Weeks 12-28 (Follow-Up Period)

Conditions

Depression

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Depression

NCT06361095

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Institute for Mental Health Research

    Austin, Texasstudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Christopher G Beevers, PhD · PRINCIPAL_INVESTIGATOR · UT Austin

Who to contact

Christopher G Beevers, PhD
[email protected]
5124717557
Email the study team

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Eligibility criteria

Inclusion

Provided informed consent
Fluent in English
Scored 13 or greater on the QIDS-SR at the baseline assessment
Between the ages of 18 to 70
Have had no changes in medication and dosage in the past 12 weeks (if currently on antidepressant medication)

Exclusion

Reported suicidal behavior or significant suicidal ideation within the past six months using the Columbia-Suicide Severity Rating Scale (C-SSRS)
Met criteria for current or past bipolar or psychotic disorders
Current (i.e., within the past 12 months) substance use disorders of moderate or greater severity on the Mini International Neuropsychiatric Interview (MINI)
Currently taking opioid analgesics or systemic corticosteroid use as these medications
Currently receiving psychotherapy

What this trial measures

  • QIDS (Quick Inventory of Depression Symptoms) SR-16Screening, Baseline, Weeks 1-4 (Acute Period), Weeks 12-28 (Follow-Up Period)

    The Quick Inventory of Depressive Symptoms (QIDS) is a 16-item measure (self-report and clinician-rated versions) for adults with depression with solid psychometric properties and substantial data supporting sensitivity to change. The QIDS assesses the criterion domains used to diagnose a major depressive disorder. The participant must score a minimum of 13 on the QIDS-SR at the baseline assessment to qualify for participation. Total QIDS scores range from 0 to 27, with higher scores reflecting greater severity of depression, and thus, worst outcomes for our study.