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Cognitive Function Study for Older ICU Survivors

This study is looking at ways to improve thinking and memory skills (cognitive function) in older adults (age 60 and older) who have been in the intensive care unit (ICU). Many ICU survivors experience problems with their memory and thinking, sometimes similar to early Alzheimer's disease. This study tests if using earplugs and eye masks at night (SLEEP intervention) and/or doing daily 30-minute computerized brain training exercises (COG intervention) can help. There's also an active control group (AC) that receives educational modules. Researchers will compare these interventions to see which ones are most effective at improving cognitive function after hospital discharge, and at 1 and 6 months later. The study aims to enroll 100 participants.

Study design
This study is an interventional study with 100 participants. It uses a 2x2 factorial design, meaning participants will be randomly assigned to one of four groups receiving different combinations of interventions.
What's involved
Participants will receive either the SLEEP intervention (ear plugs and eye masks), the COG intervention (daily 30-minute computerized cognitive training), a combination of both, or educational modules (AC). Cognitive function will be measured after the intervention, and again at 1 and 6 months after hospital discharge.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for cognitive function at 1 month and 6 months after hospital discharge.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06411561

A Multi-Modal Combination Intervention to Promote Cognitive Function in Older Intensive Care Unit Survivors

Recruiting
NAAges 60+InterventionalTreatment
University of Washington
~100 participants
Updated 2025-07-20 on ClinicalTrials.gov
What's tested:SLEEP + COGCOGSLEEPAC

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cognitive function
Measured over Post-intervention/within 7 days of hospital discharge
+3 more outcomes measured

Conditions

Critical Illness
Delirium
Cognitive Impairment
Cognitive Decline
Alzheimer's Disease
Dementia
Circadian Dysrhythmia
Sleep Disturbance

Explore related trials

Alzheimer's DiseaseArrhythmiaCognitive DysfunctionCritical IllnessDeliriumDementiaSleep Disorder

Where it's being run

1 sites across 1 states
Washington1

Study leadership

  • Maya N Elias, PhD, MA, RN · PRINCIPAL_INVESTIGATOR · University of Washington

Who to contact

Maya N Elias, PhD, MA, RN
[email protected]
206-543-8564
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age greater than or equal to 60 years old
Current hospitalization at University of Washington Medical Center or Harborview Medical Center
Intensive care unit (ICU) length of stay greater than 24 hours
Recovery from critical care status to acute care status, and/or discharge out of ICU
Fluent in English or Spanish
Functional independence on activities of daily living prior to hospitalization (Katz Index = 6)

Exclusion

Documented history or suspicion of Alzheimer's disease or dementia, or current prescription of anti-dementia medication
Documented history of bipolar disorder or schizophrenia
Documented acute stroke or traumatic brain injury
Severe vision impairment
Severe hearing impairment
Severe paralysis or dominant arm paresis
Transfer from skilled nursing care facility or inpatient rehabilitation facility

What this trial measures

  • Cognitive functionPost-intervention/within 7 days of hospital discharge

    RBANS Update: Repeatable Battery for the Assessment of Neuropsychological Status; total index score, range: 40-160; higher scores indicate better performance

  • Cognitive functionFollow-up at 1 month post-hospital discharge

    RBANS Update: Repeatable Battery for the Assessment of Neuropsychological Status; total index score, range: 40-160; higher scores indicate better performance

  • Cognitive functionFollow-up at 6 months post-hospital discharge

    RBANS Update: Repeatable Battery for the Assessment of Neuropsychological Status; total index score, range: 40-160; higher scores indicate better performance

  • Cognitive functionFollow-up at 12 months post-hospital discharge

    RBANS Update: Repeatable Battery for the Assessment of Neuropsychological Status; total index score, range: 40-160; higher scores indicate better performance