Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID) for Teens with Substance Use Problems

This study is testing a new approach called the Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID). This program aims to help teenagers (ages 13-21) who are receiving treatment for substance use problems and also have internalizing disorders (like depression or anxiety). Fam-AID involves engaging caregivers, reframing family challenges, and analyzing the teen's symptoms. The study will enroll 60 participants. Researchers will measure how well the Fam-AID program is delivered (treatment fidelity), how involved families are, and changes in internalizing disorder symptoms over six months. To join, teens must be 13-21, live with a caregiver who can attend sessions, meet criteria for substance use treatment, and have symptoms of an internalizing disorder. The current recruitment status is unclear.

Study design
This is an interventional study planning to enroll 60 participants. The phase of the study is not specified.
What's involved
Participants will attend treatment sessions, and a primary caregiver must also attend. The study will track progress from the start up to 6 months.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for 6 months after starting the study.

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NCT06413979

Family Support Protocol for Adolescent Internalizing Disorders

Recruiting
NAAges 13–21InterventionalTreatment
The National Center on Addiction and Substance Abuse at Columbia University
~60 participants
Updated 2026-04-17 on ClinicalTrials.gov
What's tested:Family Support Protocol for Adolescent Internalizing Disorders (Fam-AID)

At a glance

Recruiting sites
4 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Treatment Fidelity
Measured over Baseline to 6 months follow-up
+3 more outcomes measured
Internalizing Disorders
Substance Use Disorders
4 sites across 4 states
Florida1
Illinois1
Indiana1
New York1

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Eligibility criteria

Inclusion

Youth is age 13-21.
Youth lives with a primary caregiver who can attend treatment sessions.
Youth endorses one or more DSM-5-TR symptoms for SUD and meets American Society of Addiction Medicine criteria for outpatient SU treatment.
Youth meets DSM-5-TR criteria, or has elevated symptoms and impairment, for any of the following IDs: Current or Recurrent Major Depressive Episode, Pervasive Depressive Disorder, Social Anxiety Disorder, Generalized Anxiety Disorder, Panic Disorder, Posttraumatic Stress Disorder.
Youth completes intake and is enrolled as an active case at study site

Exclusion

Illness requiring hospitalization
Current psychotic symptoms
Severe SU problems that require immediate relief (detox or residential placement)
Pervasive developmental disorder.
  • Treatment FidelityBaseline to 6 months follow-up

    Therapist and observer report on dose of treatment delivered using Fam-AID Fidelity Checklist. The checklist will measure extensiveness of treatment technique use on a 3-point scale from 0 = not at all to 2 = quite a bit/extensively. The checklist will be developed during the study pilot phase.

  • Family InvolvementBaseline to 6 months follow-up

    Family member session attendance in terms of number of sessions attended.

  • Internalizing disorder symptomsBaseline to 6 months follow-up

    Adolescent and caregiver report on Revised Children's Anxiety and Depression Scale (RCADS). RCADS is a 47-item measure of youth's anxiety and depressive symptoms rated on a 4-point scale from 0 = Never to 3 = Always (range = 0 to 141). Higher numbers represent greater anxiety and depression.

  • Emotion RegulationBaseline to 6 months follow-up

    Adolescent and caregiver report on Difficulties in Emotion Regulation Scale (DERS). DERS is a 16-item scale assessing difficulties with emotion regulation on a 5-point scale from 1 = almost never to 5 = almost always (range - . Higher numbers indicate greater difficulties regulating emotions.