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Real Time fMRI Neurofeedback for Suicide-Specific Rumination in Veterans

This study is looking at a new way to help Veterans who experience repetitive, negative thoughts about suicide (suicide-specific rumination). It uses Real Time fMRI Neurofeedback, which is a technique that shows you your own brain activity in real-time. The goal is to help you learn to change brain activity linked to these thoughts. This is a small, initial study to see if this approach is practical and acceptable to Veterans. You may be able to join if you are a U.S. military veteran between 18-65, have a certain score on a suicide rumination scale, are stable on your medications, and are already receiving mental health care. The study will measure how acceptable and practical this treatment is two weeks after your first neurofeedback session.

Study design
This is an interventional study with a planned enrollment of 15 participants. It is not specified if it is randomized or blinded.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The primary endpoint is measured 2 weeks following the first real-time fMRI neurofeedback session.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06481033

Suicide Specific Rumination in Veterans

Completed
NAAges 18–65Interventional
VA Office of Research and Development
~16 participants
Updated 2026-08-19 on ClinicalTrials.gov
What's tested:Real Time fMRI Neurofeedback

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Acceptability and Feasibility
Measured over Total score obtained 2 weeks following first real-time fMRI neurofeedback session.

Conditions

Depression
Suicide
Mood Disorders

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DepressionMood DisorderSuicide

Where it's being run

1 sites across 1 states
New York1

Study leadership

  • Philip R Szeszko, PhD · PRINCIPAL_INVESTIGATOR · James J. Peters Veterans Affairs Medical Center

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

U.S. military Veteran
negative pregnancy test on MRI scan days
score greater than or equal to 10 on the Suicide Rumination Scale
clinically stabilized on psychotropic medications
engaged in mental health care treatment
able to provide written, informed consent

Exclusion

no major medical or neurological disorders that could interfere with treatment
moderate or severe traumatic brain injury
current imminent suicide risk, as determined through psychiatric interview, responses to C-SSRS, and clinical judgment of the assessor
any current psychotic disorder
MRI contraindications
any substance use disorder for substances other than cannabis or alcohol (mild alcohol or cannabis use disorder does not exclude participants but moderate or severe alcohol or cannabis substance use disorder is disqualifying)
pregnant or trying to become pregnant

What this trial measures

  • Acceptability and FeasibilityTotal score obtained 2 weeks following first real-time fMRI neurofeedback session.

    The Client Satisfaction Questionnaire will be used to assess acceptability and feasibility of implementing real-time fMRI neurofeedback in a Veteran population. The total score on the questionnaire ranges from from 8 to 32 with higher scores indicative of greater satisfaction.