End-Tidal Oxygen for Intubation in the Emergency Department

This study is looking at whether using an end-tidal oxygen (ETO2) monitor can help reduce the risk of hypoxia (low oxygen levels) during intubation in the Emergency Department. Intubation, also called Rapid Sequence Intubation (RSI), is a procedure where a breathing tube is placed into your windpipe. Before this, you are given extra oxygen (preoxygenation) to prevent your oxygen levels from dropping. The ETO2 monitor measures the oxygen you breathe out, giving doctors a real-time look at how well the preoxygenation is working. This study aims to see if having this information available in the ED can make intubation safer. You might be able to join if you are 18 or older, in the ED resuscitation bay, and are considered at high risk for hypoxia during intubation by your doctor. The study plans to include 1400 participants.

Study design: This is an interventional study, meaning participants will receive a specific intervention (use of an ETO2 monitor). It aims to enroll 1400 participants.
What's involved: Not specified in the trial record.
Compensation: Not stated in the trial record.
Follow-up: The primary outcome, incidence of hypoxia, is measured from when the laryngoscope enters the mouth until 2 minutes after the breathing tube is confirmed.

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End-Tidal Oxygen for Intubation in the Emergency Department

Recruiting

NAAges 18+InterventionalDiagnostic

Sydney Local Health District

~1,400 participants

Updated 2024-09-19 on ClinicalTrials.gov

What's tested:End-tidal oxygen monitor

At a glance

Recruiting sites

3 of 9 listed sites are recruiting right now

RecruitingSuspended, closed, or not yet open

What they're measuring

Incidence of hypoxia

Measured over The time when laryngoscope first enters the mouth to 2 minutes after the endotracheal tube [ETT] is confirmed on waveform capnography

Conditions

Critical Illness

Hypoxia

Respiratory Failure

Where it's being run

9 sites across 5 states

New South Wales5

Minnesota1

New Mexico1

New York1

Victoria1

Study leadership

Matthew Oliver, MBBS · STUDY_CHAIR · Sydney Local Health District
Nick Caputo, Md · STUDY_CHAIR · Lincoln Medical Center

Who to contact

Matthew Oliver, MBBS

[email protected]

+61410188680

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Eligibility criteria

Inclusion

Any patient requiring any form of oxygen therapy before preoxygenation.

Any patient with respiratory pathology based on clinical or radiological findings. Including, but not limited to:

Pneumonia, pulmonary oedema, acute respiratory distress syndrome (ARDS), aspiration, pulmonary contusion from trauma, infective exacerbations of known lung disease (e.g. asthma, pulmonary fibrosis, emphysema) or pulmonary embolism (PE)

Any patient with high oxygen consumption. Including, but not limited to:

Sepsis, Diabetic ketoacidosis, alcohol or drug withdrawal, seizures, thyrotoxicosis

Any underlying patient condition that may predispose to hypoxemia. Including, but not limited to:

Obesity, pregnancy, underlying lung disease (e.g. asthma, pulmonary fibrosis, emphysema), severe injury- hypovolaemia/haemorrhage.

or any other patient that the treating clinician has a high concern for hypoxemia during RSI.

What this trial measures

Incidence of hypoxiaThe time when laryngoscope first enters the mouth to 2 minutes after the endotracheal tube [ETT] is confirmed on waveform capnography
The proportion of patients that experience oxygenation desaturation (SpO2 \<93%, or \>10% from baseline if SpO2 \<93% at the end of preoxygenation) during the peri-intubation period

Trialytics