Neuroscience of Psychotherapy for Depression Study

This study aims to understand how the brain activity of a client and therapist might synchronize during therapy for depression. It compares two approaches: Behavioral Activation, a type of talk therapy focused on changing behaviors, and Psychoeducation, which provides general information about mental health. You could be eligible if you are between 18 and 30 years old, a full-time student, and have mild to moderate depression symptoms. The study will measure brain activity using EEG (electroencephalography) during a single therapy session and ask you to complete surveys about your mental and physical health. The main goal is to see how brain synchronization in specific frequency bands (Alpha and Theta) changes during the therapy session.

Study design
This is a pilot interventional study with a planned enrollment of 45 participants. It compares two behavioral interventions: Psychoeducation and Behavioral Activation.
What's involved
You would answer questions about your health, attend one therapy session with simultaneous brain activity measurement, and complete follow-up surveys two weeks and one month later.
Compensation
Not stated in the trial record.
Follow-up
Participants will complete follow-up surveys two weeks and one month after the intervention.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06696001

Neuroscience of Psychotherapy for Depression

Recruiting
NAAges 18–30InterventionalTreatment
University of North Carolina, Chapel Hill
~45 participants
Updated 2026-08-27 on ClinicalTrials.gov
What's tested:PsychoeducationBehavioral Activation

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Inter-brain phase synchronization in Alpha frequency band via Phase Locking Value
Measured over During the interventional session, approximately 60 minutes
+1 more outcome measured
Depression

NCT06696001

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Carolina Center for Neurostimulation

    Chapel Hill, North Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

  • Flavio Frohlich · PRINCIPAL_INVESTIGATOR · Carolina Center for Neurostimulation

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Eligibility criteria

Inclusion

Between ages 18 and 30
Full-time student status (undergraduate, graduate, and professional)
Experience mild to moderate depressive symptoms as determined by the Beck Depression Inventory (score: 14-28)
Capacity to understand study procedures (informed consent)
Ability to speak and understand English
Willingness to comply with study procedures
Ages 18 or older
Qualification to administer therapy (decided by the Principal Investigator)
Capacity to understand the study procedures (informed consent)
Speak and understand English
Willingness to comply with study procedures

Exclusion

Active, Current Suicidal ideation as determined by the Columbia-Suicide Severity Rating Scale (C-SSRS) in the past month
Past suicidal attempt (lifetime)
Recently initiated psychotherapy (past month)
Elevated psychosis risk based on self-report prodromal questionnaire - brief version (PQ-B) or self-reported diagnosis of psychotic disorder by mental health provider
Positive screen for autism spectrum disorder based on the self-report autism quotient (AQ-10) or self-reported diagnosis of autism spectrum disorder by mental health provider,
Daily intake of benzodiazepine of \>20 mg diazepam milligram equivalent
Inability to give informed, voluntary, written consent to participate
Inability to effectively communicate in English as determined by interaction with study personnel
Anything else that in the assessment of the study team is not conducive to the successful completion of the study requirements.
  • Inter-brain phase synchronization in Alpha frequency band via Phase Locking ValueDuring the interventional session, approximately 60 minutes

    Inter-brain synchronization will be calculated for the Alpha frequency band via phase locking value during the interventional session for both study arms and will be used to assess any potential differences in Alpha frequency inter-brain synchronization between groups

  • Inter-brain phase synchronization in Theta frequency band via Phase Locking ValueDuring the interventional session, approximately 60 minutes

    Inter-brain synchronization will be calculated for the theta frequency band via phase locking value during the interventional session for both study arms and will be used to assess any potential differences in Theta frequency inter-brain synchronization between groups