Stress and Pain in People Living With HIV
This study is looking at how stress and pain affect people living with HIV, especially those who also have depression and cannabis use disorder. Researchers want to understand how stress impacts the body's systems (like hormones) and how this relates to feelings of distress, cravings, and substance use. You would participate in two experimental sessions, 1-3 days apart, involving a stress task called the Yale Pain Stress Task (YPST). The study will measure changes in stress hormones like cortisol and ACTH, and pain levels. To join, you need to be 18-68 years old, able to read English, and have HIV with an undetectable viral load and good adherence to your HIV medication. Some groups will also need to meet criteria for cannabis use disorder and major depression. The study is currently recruiting 120 participants, but its overall status is unclear.
- Study design
- This is an interventional study involving 120 participants, divided into four groups, with and without HIV and other conditions. The study uses a specific stress task (YPST) in two experimental sessions.
- What's involved
- You would be scheduled for two experimental sessions, 1-3 days apart, involving the Yale Pain Stress Task. The study will also include a follow-up phase to assess drug use and mood symptoms.
- Compensation
- Not stated in the trial record.
- Follow-up
- Changes in cortisol, ACTH, and pain stress will be measured at day 1 and day 3. There is also a follow-up phase to assess drug use and mood symptoms, but its duration is not specified.
AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.
Stress and Pain in People Living With HIV
At a glance
Conditions
Where it's being run
1 sites across 1 statesStudy leadership
- Rajita Sinha, Ph.D. · PRINCIPAL_INVESTIGATOR · Yale University
Who to contact
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Do you actually qualify for this trial?
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Inclusion
Exclusion
What this trial measures
- Change in cortisol levelsday 1 and day 3
Mean change in cortisol levels (pg/ml) assessed using repeated blood sampling over 2 hour period on 2 separate days to extract plasma for cortisol measurement using standard RIA assay procedures.
- Change in adrenocorticotropic hormone (ACTH) levelsday 1 and day 3
Mean change in pain stress assessed using repeated blood sampling over 2 hour period on 2 separate days to extract plasma for ACTH measurement using standard RIA assay procedures.
- Change in pain stressday 1 and day 3
Mean change in pain stress assessed using repeated sampling over 2 hour period on 2 separate days using 10-point visual analog scales (VAS) where 0 is not at all and 10 is the most pain being experienced.