This study is looking at how well different types of repetitive Transcranial Magnetic Stimulation (rTMS) can help people with Major Depressive Disorder or Treatment Resistant Depression stay well after they've already responded to rTMS treatment. rTMS uses magnetic pulses to stimulate brain cells. The study compares two active rTMS approaches, "standard maintenance rTMS" and "clustered maintenance rTMS," to a "sham maintenance rTMS" (a placebo treatment). Researchers want to see how these treatments affect brain connections (DLPFC-SGC connectivity) over six months. You could join if you are 18 to 80 years old, have responded to rTMS for depression, and meet other specific criteria. The study aims to enroll 75 participants across three sites.

Study design

This is a double-blind, three-arm maintenance treatment trial involving 75 participants. Participants will be randomly assigned to receive one of the three rTMS treatments.

What's involved

Participants will receive either standard, clustered, or sham maintenance rTMS over a 6-month period. The study will measure brain connections at 6 months.

Compensation

Not stated in the trial record.

Follow-up

The primary endpoint is measured at 6 months, indicating a follow-up period of at least that duration.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.