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Digital Mental Health Intervention for Chronic Pain, Depression, and Anxiety

This study is testing and improving a mobile app called Wysa for Chronic Pain. This app helps people who have chronic pain along with symptoms of depression and/or anxiety. It uses tools like behavioral activation (encouraging positive activities), cognitive behavioral therapy, mindfulness, and sleep support. The study will refine the in-app notifications, called Just-In-Time Adaptive Interventions (JITAIs), to make the app more helpful. You might be able to join if you are 45 or older, have chronic pain, and experience moderate to severe depression or anxiety. The main goal is to see how much people use and engage with these in-app notifications. This version of the app is not yet available to the public.

Study design
This interventional study plans to enroll 1000 participants. It will test and refine multiple digital interventions through a series of randomized trials.
What's involved
You would download and use the Wysa for Chronic Pain study app for several weeks. You will also complete brief surveys about your mood, pain, physical function, and sleep at the beginning and end of the study.
Compensation
Not stated in the trial record.
Follow-up
Engagement with the in-app notifications will be measured over varying time intervals, from 24 hours to 7 days.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT06978166

Just-In-Time Adaptive Interventions (JITAIs) in a Digital Mental Health Intervention for Middle-Aged and Older Adults With Chronic Pain

Recruiting
NAAges 45+InterventionalSupportive care
Washington University School of Medicine
~1,000 participants
Updated 2026-05-05 on ClinicalTrials.gov
What's tested:Just-In-Time Adaptive Interventions (JITAIs)Wysa for Chronic Pain

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Engagement
Measured over Each JITAI has a different target engagement time interval. e.g., varying from 24 hours to 7 days.

Conditions

Chronic Pain
Depression, Anxiety

Explore related trials

AnxietyChronic PainDepression

NCT06978166

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Washington University in St. Louis School of Medicine

    St Louis, Missourino site contact published

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Abby L. Cheng, MD, MPHS · PRINCIPAL_INVESTIGATOR · Washington University School of Medicine

Who to contact

Adriana Martin
[email protected]
314-530-9023
Email the study team

Opens a ready-to-send draft in your own email app — review before sending.

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Eligibility criteria

Inclusion

45 years or older
At least moderately severe depression and/or anxiety symptoms (Patient Health Questionnaire-9 (PHQ-9) and/or Generalized Anxiety Disorder-7 (GAD-7) score ≥ 10)
Chronic pain (i.e., pain on most days or every day in the past three months)

Exclusion

Frequent active suicidal ideation
No access to a mobile device
Not living in the United States

What this trial measures

  • EngagementEach JITAI has a different target engagement time interval. e.g., varying from 24 hours to 7 days.

    The primary outcome for each JITAI is the between-group difference in engagement with Wysa for Chronic Pain during the JITAI's target engagement time interval. Engagement is operationalized as interaction(s) with the digital mental health intervention and is automatically captured throughout the study by the intervention's technical infrastructure. It is not self-reported.