Smartphone App (HippoCamera) for Memory in Teens and Young Adults with Down Syndrome

This study is looking at how a smartphone app called HippoCamera might help teens and young adults (ages 15-35) with Down syndrome improve their memory. People with Down syndrome often have difficulty remembering specific details from past events. The HippoCamera app asks you to record one event each day and then replay some of those recorded events. Researchers want to see if replaying these memories helps you remember them more clearly. To join, you need a diagnosis of Down syndrome, daily access to a smartphone, and the ability to use the HippoCamera app with some support. The study will measure how well you remember details from events at the beginning, right after using the app for three months, and then six weeks later.

Study design
This is an interventional study planning to enroll 40 participants. Half of the recorded memories in the HippoCamera app will be categorized as 'baseline' and half as 'replay'.
What's involved
You would use the HippoCamera app daily for three months, recording one event and replaying up to five events. Memory tests will be conducted at the start, immediately after the three-month intervention, and six weeks later.
Compensation
Not stated in the trial record.
Follow-up
Your memory will be assessed six weeks after the intervention ends.

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NCT07008989

A VIRTUAL Three-month Intervention Study of the Effects of a Smartphone Application (HippoCamera) on Memory in Teens and Young Adults With Down Syndrome

Recruiting
NAAges 15–35InterventionalBasic science
Boston College
~40 participants
Updated 2026-07-14 on ClinicalTrials.gov
What's tested:Memory replay

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Internal detail
Measured over Baseline memory appointment (immediately prior to intervention), immediate post-treatment appointment (within a week of terminating intervention), and follow-up appointment (6 weeks after terminating intervention).
Memory Replay
HippoCamera
1 sites across 1 states
Massachusetts1

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Eligibility criteria

Inclusion

Diagnosis of Down syndrome
Daily access to a smart phone
The ability to create and replay memories using HippoCamera with limited support from a guardian
Informed consent obtained from parent or guardian (or participant, if legally independent)
Informed verbal assent obtained from participant
Ability to comprehend instructions, denoted by parent/guardian acknowledgment
English as a primary written and spoken language
Normal or corrected-to-normal vision and hearing
All races/ethnicities and socio-economic statuses

Exclusion

Autism
Non-native speaker of English (acquired after the age of 5)
  • Internal detailBaseline memory appointment (immediately prior to intervention), immediate post-treatment appointment (within a week of terminating intervention), and follow-up appointment (6 weeks after terminating intervention).

    All memory narratives will be transcribed and scored using the Autobiographical Interview protocol. Highly trained raters will score each autobiographical memory according to the number and proportion of episodic (internal) vs. semantic (external) details. Episodic details are specific to the time and place of the targeted event, whereas semantic details involve factual information or extended events that do not require recollection of a specific time and place. Memory for episodic details requires the hippocampus, whereas memory for semantic details is more resistant to hippocampal damage.