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Physical Capacity Building for Chronic Stroke

This study is looking at a program called "Physical capacity training for chronic stroke - building aerobic capacity and muscle strength" (PC3-BAMS) for people who have had a stroke. This program is similar to cardiac rehabilitation, which helps people recover after heart problems. Researchers want to see if this 12-week exercise program can improve physical abilities and mental well-being in stroke survivors, including those with post-stroke depression. You might be able to join if you are 18-80 years old, had a stroke at least six months ago, have some weakness in your leg, and can walk without help. The study will measure improvements in walking ability, how stroke affects your daily life, and symptoms of depression. The current status of this study is unclear.

Study design
This is an interventional study with a planned enrollment of 76 participants. It is testing a specific exercise program.
What's involved
Each exercise session includes checking heart rate and blood pressure, a warm-up, at least 30 minutes of aerobic exercise, and 25 minutes of resistance exercise. The program lasts for 12 weeks.
Compensation
Not stated in the trial record.
Follow-up
Your progress will be measured from when you join until the end of the 12-week treatment period.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07039305

Physical Capacity Building for Chronic Stroke

Recruiting
NAAges 18–80InterventionalTreatment
Medical University of South Carolina
~76 participants
Updated 2025-12-08 on ClinicalTrials.gov
What's tested:Physical capacity training for chronic stroke - building aerobic capacity and muscle strength

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Six-minute walk test
Measured over From enrollment to the end of treatment at 12 weeks
+2 more outcomes measured

Conditions

Stroke
Post-stroke Depression

Explore related trials

DepressionStroke

NCT07039305

Where you'd take part

This study runs at 1 site. They're the same protocol — you choose where, and that choice sets who your contact draft is addressed to.

  • Medical University of South Carolina

    Charleston, South Carolinastudy coordinator listed

    Recruiting

Sites open and close at different times, so the status above is per site — it can differ from the study's overall status.

Study leadership

  • Ryan Ross · PRINCIPAL_INVESTIGATOR · Medical University of South Carolina

Who to contact

Ryan E Ross, Ph.D.
[email protected]
843-792-3477
Email the study team

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Eligibility criteria

Inclusion

Age 18-80
A diagnosis of stroke at least 6 months prior
Residual paresis in the lower extremity (Fugl-Meyer lower extremity \[LE\] motor score \<34)
Ability to walk without assistance and without an AFO during testing and training at speeds ranging from 0.2-1.0 m/s
Ability to follow instructions, complete cognitive testing and to communicate exertion, pain and distress
No antidepressant medications or no change in doses of psychotropic medication for at least 4 weeks prior to the study (6 weeks if newly initiated medication)
HDRS17 question #3 and PHQ-9 question #9 regarding suicide ≤ 2
Provision of informed consent.

Exclusion

Unable to ambulate at least 150 feet or experienced intermittent claudication while walking
Unstable cardiac arrhythmias, hypertrophic cardiomyopathy, severe aortic stenosis, angina or dyspnea at rest or during ADL's
Dementia
Life expectancy \<1 yr
History of DVT or pulmonary embolism within 6 months
Uncontrolled diabetes with recent weight loss, diabetic coma, or frequent insulin reactions
Severe hypertension with systolic \>200 mmHg and diastolic \>110 mmHg at rest
Attempt of suicide in the last 2 years or suicidal risk assessed by depression screening
Current enrollment in a rehabilitation trial to enhance motor, cognitive and or psychosocial recovery
Severe cognitive impairment (MoCA score ≤15)
Moderate to severe neglect that precludes cognitive testing
Electronic or metallic implants
History of seizures
Women of child bearing potential

What this trial measures

  • Six-minute walk testFrom enrollment to the end of treatment at 12 weeks

    Distance walked in six minutes.

  • Stroke Impact ScaleFrom enrollment to the end of treatment at 12 weeks

    The SIS assesses post-stroke recovery across eight domains - social participation, emotion, communication, memory, mobility, strength, hand function, and activities of daily living - as well as subjective extent of overall recovery.

  • Hamilton Depression Rating Scale - 17From enrollment to the end of treatment at 12 weeks

    The Hamilton Depression Rating Scale interview contains 17 items that assess the severity and frequency of depressive symptoms over the previous week.