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Remote Exercise and Caregiver Support for Down Syndrome and Alzheimer's Disease

This study is testing a 12-week program called "Adapting RDAD for DS" to help older adults with Down syndrome (DS) and their caregivers. The program includes remote exercise sessions for individuals with DS, using pre-recorded videos and a staff member on video calls to help. Caregivers will also join weekly video calls for education and support on managing challenging behaviors related to Alzheimer's disease (AD) symptoms. The main goal is to see if this program is practical to deliver and if it shows early signs of being helpful. We are looking for adults with Down syndrome over 35 years old who can understand and communicate. This study is currently recruiting 40 participants.

Study design
This is a 12-week pilot study with 20 adults with Down syndrome and their caregivers. It is a single-arm trial, meaning all participants receive the intervention.
What's involved
You would participate in three 30-minute exercise sessions per week via video call for 12 weeks. Caregivers would also attend one 40-minute weekly education session via video call. Staff will visit your home at the beginning and end of the study for assessments and equipment setup.
Compensation
Not stated in the trial record.
Follow-up
Participants will be assessed at baseline and after 12 weeks, which is the duration of the intervention.

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NCT07425769

Adapting RDAD for DS

Recruiting
NAAll AgesInterventionalSupportive care
University of Kansas Medical Center
~40 participants
Updated 2026-08-03 on ClinicalTrials.gov
What's tested:Remote Exercise SessionsCaregiver Education Sessions

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Feasibility: Participant Recruitment
Measured over Baseline
+4 more outcomes measured

Conditions

Down Syndrome (DS)
Alzheimer's Disease (AD)

Explore related trials

Alzheimer's DiseaseDown Syndrome

Where it's being run

1 sites across 1 states
Kansas1

Study leadership

  • Amy Bodde, PhD · PRINCIPAL_INVESTIGATOR · University of Kansas Medical Center

Who to contact

Amy Bodde, PhD
[email protected]
913-574-2447
Email the study team

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Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Age \>35 yrs. with a diagnosis of DS as self-reported or reported by caregiver. This age range was selected as cognitive decline related to AD is observed at age \~31 in adults with DS.
Sufficient functional ability to understand directions, communicate preferences, wants, and needs through spoken language.
Living at home or in a supported living environment with a parent/caregiver who agrees to serve as a study partner.
Self-reported ability to participate in physical activity.
Age ≥18 yrs.
Reports being a primary caregiver of an adult with DS.
English speaking.
Self-reported ability to participate in physical activity.

Exclusion

Unable to participate in moderate-to-vigorous physical activity.
Self-reported, cardiovascular, metabolic or renal disease and/or signs or symptoms.
Unable to participate in moderate PA, i.e., brisk walking.
Self-reported, cardiovascular, metabolic or renal disease and/or signs or symptoms.

What this trial measures

  • Feasibility: Participant RecruitmentBaseline

    Number of participants enrolled divided by number eligible on questionnaire

  • Feasibility: Recruitment RateBaseline

    Number of participants enrolled per month of active recruitment

  • Feasibility: Participant retentionBaseline to Week 12

    Calculated as number of participants completing the intervention divided by the number who initiate the intervention multiplied by 100

  • Feasibility: Session AttendanceAcross 12 week intervention

    Calculated as the percentage of sessions attended across 12 weeks.

  • Feasibility: Participant SafetyAcross 12 week intervention

    Will be expressed as the total number of self-reported adverse events.