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Observational Study on Stimulant and Polysubstance Use, Inflammation, and Heart Disease in HIV

This observational research study is looking at how using stimulants and other substances affects scarring and inflammation in the heart of people with HIV. It's also exploring how sex (male or female) plays a role. The study aims to understand these connections by looking at your heart using a special scan called a cardiac MRI. You can join if you are 30 years or older and are already part of the MACS/WIHS Combined Cohort Study (MWCCS) at specific sites. The study plans to include 400 participants. Success for this study means understanding the impact of substance use on heart health in people with HIV. The current recruitment status is unclear.

Study design
This is an observational study, meaning researchers will observe and collect information without providing any interventions. It plans to enroll 400 participants.
What's involved
You would have one study visit for a cardiac MRI, which takes up to 2 hours.
Compensation
Not stated in the trial record.
Follow-up
Not specified.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07461350

Stimulant and Polysubstance Use, Inflammation, and Sex Effects on Myocardial Disease in HIV

Enrolling by Invitation
Not specifiedAges 30+Observational
University of California, San Francisco
~400 participants
Updated 2026-08-11 on ClinicalTrials.gov

At a glance

Recruiting sites
0 of 4 listed sites are recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Cardiac MRI
Measured over Visit 1, up to 2 hours

Conditions

HIV (Human Immunodeficiency Virus)

Explore related trials

CardiomyopathyHIV InfectionSubstance use disorder

Where it's being run

4 sites across 4 states
California1
Georgia1
Maryland1
New York1

Study leadership

  • Phyllis Tien, MD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco
  • Elise Riley, PhD · PRINCIPAL_INVESTIGATOR · University of California, San Francisco

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

Add a private profile and we'll compare every criterion below against your situation — and tell you which ones are met, uncertain, or excluding.

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Eligibility criteria

Exclusion

Standard contraindications to MRI
claustrophobia,
metal implants,
large body size (weight \>350 lbs or abdominal sagittal diameter \>70 cm),
pregnancy)
Gadolinium risk
severe or uncontrolled asthma,
visit day eGFR\<45 ml/min/1.73 m2;
poor venous access
pregnancy or lactation

What this trial measures

  • Cardiac MRIVisit 1, up to 2 hours

    CMR assessments to provide detailed myocardial characterization (e.g. diffuse inflammation (nT1), myocardial fibrosis (ECV), and myocardial scar assessed using LGE)