Metric-Optimized Spectacles for Children With Down Syndrome

This study is looking at whether a special type of glasses prescription, called Metric-optimized spectacles, can improve vision for children with Down syndrome better than regular glasses (Routine Clinical Spectacles). Metric-optimized spectacles are made using computer analysis of detailed eye images. The study aims to enroll 24 children with Down syndrome, aged 5 to 12 years, who can sit for eye tests and have their eyes dilated. Children with certain eye conditions like nystagmus (involuntary eye movements) or a history of eye surgery cannot join. The main goal is to see if the Metric-optimized spectacles lead to better distance visual acuity (how clearly you see things far away) after 2 months.

Study design
This is a randomized, crossover study involving 24 participants. It compares two types of spectacle prescriptions.
What's involved
You would have 5 study visits over 12 months. These visits include eye exams, measuring pupil size, and wavefront aberration measurements.
Compensation
Not stated in the trial record.
Follow-up
Your distance visual acuity will be measured at 2 months after adapting to the glasses.

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NCT07490444

Metric-Optimized Spectacle Prescriptions for Children With Down Syndrome

Recruiting
PHASE2Ages 5–12InterventionalTreatment
Ohio State University
~24 participants
Updated 2026-07-20 on ClinicalTrials.gov
What's tested:Metric-optimized spectaclesRoutine Clinical Spectacles

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Adapted Distance Visual Acuity
Measured over 2 months
Refractive Error Correction
Visual Acuity
1 sites across 1 states
Ohio1

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Eligibility criteria

Inclusion

Down syndrome
Age 5 to 12 years
Ability to sit for study measures
Able to be dilated

Exclusion

Nystagmus
History of Ocular or Refractive Surgery
Corneal or lenticular opacities
Ocular disease
Anisometropic or strabismic amblyopia
Contact allergy to aluminum
  • Adapted Distance Visual Acuity2 months

    Aided LogMAR (minimum angle of resolution) distance visual acuity obtained with either British Standard Letters or HOTV - matching for participants unable to name letters