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Personalized Oxygen Targets for Acute Respiratory Failure

This study is looking at how different ways of giving oxygen to patients with acute respiratory failure (severe breathing problems) affect their recovery. You might be eligible if you are 18 or older, are in a participating hospital unit, and are on a breathing machine (invasive mechanical ventilation). The study compares two approaches: one where doctors, nurses, and respiratory therapists use a personalized oxygen target predicted to be best for you, and another where they decide on oxygen levels as they normally would. The main goal is to see if one approach leads to fewer deaths in the hospital within 28 days.

Study design
This interventional study plans to enroll 3000 participants and compares two different approaches to oxygen administration.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed from randomization until hospital discharge or 28 days after randomization, whichever comes first.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07536984

Examination of Personalized SpO2 Targets

Enrolling by Invitation
NAAges 18+InterventionalTreatment
Vanderbilt University Medical Center
~3,000 participants
Updated 2026-05-20 on ClinicalTrials.gov
What's tested:Personalized SpO2 TargetUsual Care

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
28-day in-hospital mortality
Measured over From randomization to the first of hospital discharge or 28 days after randomization

Conditions

Acute Respiratory Failure

Explore related trials

Acute Respiratory FailureCritical Illness

Where it's being run

1 sites across 1 states
Tennessee1

Study leadership

  • Matthew W Semler, MD, MSCI · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center
  • Adam Wright, PhD · PRINCIPAL_INVESTIGATOR · Vanderbilt University Medical Center
  • Jonathan D Casey, MD, MSCI · STUDY_DIRECTOR · Vanderbilt University Medical Center
  • Edward T Qian, MD, MSACI · STUDY_CHAIR · Vanderbilt University Medical Center

Who to contact

This trial hasn't published a contact. View it on ClinicalTrials.gov

Do you actually qualify for this trial?

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Eligibility criteria

Inclusion

Patient is located in a participating unit
Patient is receiving invasive mechanical ventilation

Exclusion

Patient is known to be less than 18 years old
Patient is known to be pregnant
Patient is known to be a prisoner
Patient is receiving extracorporeal membrane oxygenation
Clinician has determined that a specific approach to oxygen therapy is required or contraindicated for the optimal care of the patient

What this trial measures

  • 28-day in-hospital mortalityFrom randomization to the first of hospital discharge or 28 days after randomization

    Death from any cause by day 28