NCT07637669
Olfactory Function and Model-Based Behavior in People Living With HIV and SUD
Not Yet Recruiting
Not specifiedAges 18–65ObservationalNational Institute on Drug Abuse (NIDA)Government-funded
~120 participants
Updated 2026-08-03 on ClinicalTrials.gov
At a glance
Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Olfactory function
Measured over Visit 1
+1 more outcome measured
Conditions
Where it's being run
1 sites across 1 statesMaryland1
Study leadership
- Thorsten Kahnt, Ph.D. · PRINCIPAL_INVESTIGATOR · National Institute on Drug Abuse (NIDA)
Who to contact
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Do you actually qualify for this trial?
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Eligibility criteria
Inclusion
Stated willingness to comply with all study procedures and availability for the duration of the study
Aged 18-65 years old. Justification: prevalence of olfactory impairments increases with age; after age 53, the prevalence is 24.5 percent, increasing to 62.5 percent in people ages 80-97.
Agreement to adhere to Lifestyle Considerations throughout study duration.
Ability of subject to understand and the willingness to sign a written informed consent document.
HIV positive.
Substance Use Disorder (SUD) other than Alcohol Use Disorder (AUD) or Tobacco Use Disorder (TUD).
Exclusion
History of neurological illnesses or neurosurgery including but not limited to cerebrovascular accident, Parkinson disease, Alzheimer disease, Huntington disease, central nervous system (CNS) tumor, significant head trauma with sequelae, multiple sclerosis or other demyelinating diseases, epilepsy, movement disorders. The MAI will also retain discretion to exclude based on a history of a neurological illness or trauma that may compromise data integrity.
History of current (past 12 months) uncontrolled major DSM-5 psychiatric disorder including major affective disorder, obsessive-compulsive disorder, schizophrenia, or posttraumatic stress disorder, excluding SUD.
Candidates who recently (12 hours prior to a study visit) used medications and/or substances that are psychoactive or otherwise affect alertness will have to pass a clinical assessment for intoxication on the day of the study visit. Based on participant preferences and MAI/PI judgment, participants who fail the clinical assessment for intoxication will either be withdrawn or rescheduled.
History of clinically significant anaphylaxis, e.g., due to severe asthma or food and nonfood allergies (e.g., latex, detergents, soap, etc.). The MAI will retain discretion to exclude a participant based on this criterion.
Uncorrected impairments in visual acuity.
Non-English speaking. Justification: The data integrity of some of the behavioral tasks used in this study would be compromised as they have only been validated in English.
Pregnancy.
Any other condition that in the judgment of the investigators is incompatible with participation.
History of current (past 12 months) SUD, excluding tobacco use disorder.
Pattern of alcohol and drug use in the past 12 months that is indicative of harmful use, loss of control over use, or physical dependence.
Daily alcohol or drug use (excluding caffeine and nicotine) for at least 4 continuous weeks in the past 12 months.
HIV positive.
Unable to undergo MRI scanning due to certain metallic or magnetic devices or implants in the body, or claustrophobia.
What this trial measures
- Olfactory functionVisit 1
Sniffin Sticks Threshold, Discrimination, and Identification tests
- Model-based decision makingVisit 1 & 2
Model-based decision making as assessed in an outcome devaluation task (visit 1) and sensory preconditioning task (visit 2)