The ENHANCE Project Toolkit: Mobile Tools for Overdose Risk

This study, called The ENHANCE Project Toolkit, is looking at how practical and helpful a set of smartphone-based tools are for reducing the risk of drug overdose. It's testing a mobile health app called Connections, along with other internet and phone resources designed to help prevent overdose. We want to see if these tools are easy to use and if people find them appropriate and acceptable. The study plans to enroll 40 participants who are at least 18 years old, can read and write English, and have used certain drugs recently. This is a pilot study, meaning it's not designed to show if the tools directly improve health outcomes, but rather to gather information for future, larger studies. The current recruitment status is unclear.

Study design
This is an interventional pilot study with 40 participants. It is not designed to rigorously evaluate the effect of the intervention on participants.
What's involved
Participants will receive a mobile phone with an unlimited data plan and an orientation to overdose prevention tools. They will complete a 20-30 minute survey monthly for 6 months, and 25 participants will also do a 45-60 minute interview.
Compensation
Not stated in the trial record.
Follow-up
Participants will be on study for up to 9 months, with primary outcomes measured at up to 6 months.

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NCT07649278

The ENHANCE Project Toolkit

Recruiting
NAAges 18+InterventionalDevice feasibility
University of Wisconsin, Madison
~40 participants
Updated 2026-07-14 on ClinicalTrials.gov
What's tested:Connections mHealth Application

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Acceptability of Intervention Measure (AIM)
Measured over up to 6 months
+2 more outcomes measured
Substance Related Disorder
Drug Overdose
eHealth
1 sites across 1 states
Wisconsin1
  • Rachel Gicquelais, PhD, MPH · PRINCIPAL_INVESTIGATOR · UW School of Medicine and Public Health
  • Ryan Westergaard, MD, PhD, MPH · PRINCIPAL_INVESTIGATOR · UW School of Medicine and Public Health

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Eligibility criteria

Inclusion

Be at least 18 years old
Be able to read and write in English
Report drug use in the past 30 days, defined as
Any use of illicit stimulants, opioids, OR
Use of prescription opioids by a route other than "by mouth/swallowed"
Additionally report recent drug use of at least twice in the past 7 days
Have NOT used any of the following harm reduction services in the past 6 months:
In-person community-based prevention services for people who use drugs
Overdose crisis hotlines
Online mail-order prevention supply delivery
Apps for supporting addiction treatment or recovery
Be at least 18 years old
Be able to read and write in English
Have served as a member of the existing Community Leadership Team.

Exclusion

Are under the age of 18
Have impaired decision making capacity at the time of screening
Do not have the ability to participate in screening and enrollment activities in any one of the following ways:
Traveling to their nearest participating Vivent Health health center
Coordinating a visit with the Vivent Health harm reduction mobile unit
Accessing and completing the online screening survey on a personal wifi/internet enabled device
  • Acceptability of Intervention Measure (AIM)up to 6 months

    The Acceptability of Intervention Measure (AIM) measures intervention acceptability with 4 items ranked on a 5-point Likert-type scale. Participants will be asked the 4-item questionnaire for each tool offered in the bundle (3). Scores are averaged across the measure for each tool and subsequently scores for individual tools will be summed to generate a composite acceptability score of the program. Scores can range from 3-15, with higher scores meaning higher acceptability of the intervention

  • Intervention Appropriateness Measure (IAM)up to 6 months

    The Intervention Appropriateness Measure (IAM) measures intervention appropriateness with 4 items ranked on a 5-point Likert-type scale. Participants will be asked the 4-item questionnaire for each tool offered in the bundle (3). Scores are averaged across the measure for each tool and subsequently scores for individual tools will be summed to generate a composite appropriateness score of the program. Scores can range from 3-15, with higher scores meaning higher appropriateness of the intervention.

  • Feasibility of Intervention Measure (FIM)up to 6 months

    The Feasibility of Intervention Measure (FIM) measures intervention feasibility with 4 items ranked on a 5-point Likert-type scale. Participants will be asked the 4-item questionnaire for each tool offered in the bundle (3). Scores are averaged across the measure for each tool and subsequently scores for individual tools will be summed to generate a composite feasibility score of the program. Scores can range from 3-15, with higher scores meaning higher feasibility of the intervention.