COMPARE-VENT Feasibility Pilot Study for Respiratory Failure in Cardiac Patients

This study is looking at different ways to use mechanical ventilation (a machine that helps you breathe) in patients who have heart disease and also need help breathing. Specifically, it's comparing two types of ventilation: Volume Controlled Mode and Pressure Controlled Mode. The goal is to see how well these methods can be used in a cardiac intensive care unit (CICU) and how quickly patients can start on their assigned ventilation mode. You might be able to join if you are an adult (18 or older) admitted to the cardiac ICU, need invasive mechanical ventilation for more than 12 hours, and have conditions like respiratory failure or cardiogenic pulmonary edema (fluid in the lungs due to heart problems). This study aims to improve how we care for patients with heart and breathing issues.

Study design
This is an interventional pilot study planning to enroll 75 participants. It will compare two different modes of mechanical ventilation.
What's involved
Participants will be monitored from enrollment until 48 hours after starting their assigned mechanical ventilation mode.
Compensation
Not stated in the trial record.
Follow-up
Participants will be followed for adherence to the assigned study mode and time to initiation of the assigned mode, both measured from enrollment to 48 hours.

AI-generated from the public study record. Only the study team can confirm whether you're eligible — confirm details with them before making decisions.

NCT07656259

COMPARE-VENT Feasibility Pilot Study

Recruiting
NAAges 18+InterventionalTreatment
Mayo Clinic
~75 participants
Updated 2026-08-10 on ClinicalTrials.gov
What's tested:Volume Controlled ModePressure Controlled Mode

At a glance

Recruiting sites
1 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Adherance to assigned study mode (Feasibility Outcome)
Measured over Enrollment to 48 hours
+1 more outcome measured
Respiration Failure
Cardio Vascular Disease
Cardiogenic Pulmonary Oedema
Critical Illness
Mechanical Ventilation
Cardiogenic Shock
Cardiopulmonary
1 sites across 1 states
Minnesota1

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  • Adherance to assigned study mode (Feasibility Outcome)Enrollment to 48 hours

    Percentage of time spent on the assigned study mode while receiving invasive mechanical ventilation in the cardiac ICU between enrollment and 48 hours after enrollment.

  • Time From Enrollment to Initiation of Assigned Mode of Mechanical Ventilation (Feasibility Outcome)Enrollment to 48 Hours

    Time (number of hours) taken to initiate participants from enrollment (cardiac ICU admission) to initiation of assigned study mode of invasive mechanical ventilation upto 48 hours after enrollment.