Homeless Overdose Prevention- Expansion (HOPE) for Veterans

This study, called Homeless Overdose Prevention- Expansion (HOPE), is testing ways to provide overdose education and naloxone (a medication that can reverse opioid overdose) to Veterans experiencing homelessness. This includes Veterans living in supportive housing programs. The study aims to see how well these programs can reach and be used by Veterans at risk for opioid overdose. Researchers will also look at how well the programs are put into practice over 12 months. You might be able to join if you are a Veteran, at least 18 years old, enrolled in the HUD-VASH program, and identified as being at risk for opioid overdose based on existing HOPE program information. The current recruitment status is unclear.

Study design
This interventional study plans to enroll 1200 participants. It compares two approaches to providing overdose education and naloxone distribution: a low-intensity and a high-intensity behavioral intervention.
What's involved
Not specified in the trial record.
Compensation
Not stated in the trial record.
Follow-up
The study will track how well the program reaches and is adopted by participants for 12 months.

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NCT07716202

Homeless Overdose Prevention- Expansion

Not Yet Recruiting
NAAges 18+InterventionalHealth services
VA Office of Research and Development
~1,200 participants
Updated 2026-07-30 on ClinicalTrials.gov
What's tested:Homeless Overdose Prevention- Expansion (HOPE) - Low IntensityHomeless Overdose Prevention- Expansion (HOPE) - High Intensity

At a glance

Recruiting sites
0 of 1 listed site is recruiting right now
RecruitingSuspended, closed, or not yet open
What they're measuring
Reach - VA administrative data
Measured over 12 months
+3 more outcomes measured
Homelessness
Opioid Education and Naloxone Distribution (OEND)
Substance Use Disorder
1 sites across 1 states
California1
  • Amanda M. Midboe, PhD · PRINCIPAL_INVESTIGATOR · VA Palo Alto Health Care System, Palo Alto, CA

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Eligibility criteria

Inclusion

Veterans enrolled in HUD-VASH at risk for opioid overdose (based on existing HOPE algorithms aligned with Pharmacy Benefit Manager data definitions), drawing from VA administrative data.

Exclusion

Not flagged by existing HOPE algorithms
Not currently enrolled in HUD-VASH
Is not a patient at a participating site of the implementation trial
  • Reach - VA administrative data12 months

    Reach will be measured in terms of the proportion of Veterans who receive OEND, including overdose education and/or a naloxone prescription, using VA administrative data.

  • Adoption - VA administrative data12 months

    Adoption will be measured in terms of the proportion of VHA pharmacy and other prescriber staff who delivered OEND, using VA administrative data.

  • Implementation - Electronic Data Capture12 months

    Implementation will be measured in terms of adherence of sites to tailored implementation. Implementation fidelity will be captured using electronic data capture.

  • Maintenance - Rapid Qualitative Interviews6-12 months

    Maintenance will be assessed by the extent to which OEND has become part of routine organizational practices and policies, including clinical processes to maintain OEND. Maintenance will be assessed 6-12 months post-implementation using semi-structured interviews. Interviews will be conducted with HUD-VASH staff and measured using rapid qualitative methods and administrative data. Administrative data will be used to measure whether OEND continues to be provided in the maintenance period.